The loss of smell could potentially serve as an early indicator of Alzheimer's disease.
According to a study in the medical journal Neurology, individuals with the APOE e4 gene variant, associated with a higher risk of Alzheimer's disease, may experience a loss of smell as one of the early signs of the disease. The study found that carriers of this gene tend to lose their ability to detect odors (odor sensitivity) before experiencing losses in odor recognition and cognitive abilities. This suggests that the loss of smell could be an early indicator of Alzheimer's disease in individuals with the APOE e4 gene variant.
Source: healthline
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